Ultra Secret RoomTreasure RoomTreasure Room brimstone and technology have synergized since afterbirth ;v sooo it has been there for a while and yesss it is beautiful :p. Nov 2, 2015 @ 6:29am. The size resets when leaving the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Lazarus, A fetus familiar follows Isaac, and upon entering the Boss room on each floor, it will transform into a copy of the boss, This makes bosses a lot harder, however you now get 2 boss item drops, UNLOCK: Unlock this item by defeating Hush as Jacob & Esau, You gain two familiar demons, that stay by Isaac's side and fire shots in the same direction as you, The familiars deal roughly 40% of Isaac's damage, scaling with damage upgrades you get, They sit near and rotate around Isaac depending on which way you're firing tears. It also leaves a gas cloud at the place where it exploded, The bomb deals 185 damage + your tear damage on hit and leaves a damage over time poison effect that does 3 times your tear damage per tick, Synergizes with tear modifying items such as My Reflection or Tiny Planet, Has a chance to drop from the Sloth miniboss fight, Counts as 1 of 3 poison items needed towards the Bob transformation, REPENTANCE - The damage of this item was significantly boosted to 185 (from 50) in Repentance, and given the poison cloud effect. grey, gray, Gives the player an invulnerability effect which lasts for a 10 seconds, Can be used to get free hits on the Blood Donation machines and Devil Beggars, * library pool, library room, book room pool, item room, treasure room, item room pool, white, pink, Allows Isaac to walk over gaps with a width of one tile, * shop room pool, shop item pool, the lost item pool, brown, wooden, Heals half a heart after every 13 enemies killed, Works with the Keeper for restoring coin HP, * item room, treasure room, item room pool, the lost item pool, black, grey, gray, bat, All spacebar items can now be 'overcharged', allowing them to be charged up twice instead of once, The extra charges appear in yellow on top of the normal green bars, This item works with self-recharging items, * shop room pool, shop item pool, pink, purple, 15c items are reduced to 7c. Brimstone Blood laser barrage. Items Cannot be obtained and has no use for any other character, Birthright is a Shop item that has unique effects depending on what character you're playing as, This is the item Tainted Blue Baby (???) After a few seconds, he will quickly attack each target, chaining higher damage for each enemy it hits, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Judas, When used this will cause 8 poison farts that leave a brown creep behind, and then drop 7 Butt Bombs very quickly, Standing in the creep gives you +1 Damage Up and +1.35 Tears Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Blue Baby, For the current room, 14 Dead Birds fly in from off the screen and attack all enemies, dealing low but frequent damage, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eve, Isaac gains the Berserk! Each laser is emitted for about one second and hits twice, so it is possible to destroy some two-stage enemies in one shot (Globins and Hives along with the flies they spawn on death), or to strafe the shot over multiple enemies. Lazarus - Every time Lazarus dies, gives +21.6 temporary Damage Up, gradually fading over 1 minute. I do not know what is that secret room, i got the info by using a rune shard, not sure what the voice said when i used the rune. Spikes and Curse Rooms no longer deal damage, Sharp Plug becomes useless with this item, due to how damage is prevented on Isaac's body, REPENTANCE - Isaac's Heart has a charge attack, which pushes enemies away and fires blood tears in all directions. This includes all sources of damage, including environmental damage to enemies, Killing an enemy while berserk will increase the duration of the effect by 1 second, You don't die while in Berserk mode, but taking lethal damage will kill you after the effect wears off, The bone sword from this item is similar to Donkey Jawbone from Antibirth, Tainted Samson starts with a passive version of this item, UNLOCK: Unlock this item by defeating Delirium as Tainted Samson, Recharge time: Enemy damage taken = charge, When used, Isaac turns into a ghost for 1 second and his speed goes up to maximum (2.0). Not to be confused with Blood Clot, an item. Brimstone - No effect. He was born May 5, 1976, in Bangor, Maine, to James and Sarah Blood. Does not prevent Isaac from taking contact damage, All the above effects are only active when the item is used for the current room. The Knife Piece 1 is located in the Item Room in the mirrored area. Any subsequent hits give +0.4 Tears Up and will ignore the normal fire rate cap, Greatly decreases damage (x0.33 damage multiplier), Individual tears gain random worm effects (e.g. All dead names. It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. "Charged burst attack" red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. A blood clot forms through several steps: The blood vessel narrows. If it does, it will drop a random trinket, coin, heart and key, The Walnut trinket is destroyed once the effect activates, Causes any orbitals you have to stop moving while held, Stops shooting familiars from moving (including Lilith's Incubus), Some familiars with irregular movement are not affected by Duct Tape, such as Abel, BBF, Bumbo, Guppy's Hair Ball, Lil Gurdy, Punching Bag, Robo-Baby 2.0, Succubus, *, grey, gray, tp, toilet, paper, roll, silver, While held, shops will now appear on the womb floors (The Womb, Utero and Scarred Womb), UNLOCK: Unlock this item by defeating Delirium in The Void floor with Cain, While held, item rooms now appear on the womb floors (The Womb, Utero and Scarred Womb), REPENTANCE - Causes item rooms to appear on Corpse floors, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Samson, While held, restock boxes will always spawn in item rooms, *, cent, money, cash, coin, pixel, blue, green, p2w, Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies, dealing double tear damage for the impact of the Locust and 60 damage for the explosion, Can be dangerous as the fly will target the nearest enemy, which can be close enough to catch Isaac in its blast radius, UNLOCK: Unlock this trinket by defeating Isaac in the Cathedral as Apollyon, At the start of each new hostile room you spawn a green attack fly, which will target a nearby enemy, deal double your tear damage and then poison them, UNLOCK: Unlock this item by beating Satan with Apollyon, At the start of each new hostile room you spawn a yellow attack fly, which will target a nearby enemy, deal double your tear damage and apply a slowing effect to it, UNLOCK: Unlock this trinket by defeating ??? Deals 45 damage to enemies it lands on. REPENTANCE - Bob's Brain now has an increased delay before becoming available when entering rooms. It's a 20% chance on first miss, 33% for a second miss and 50% for anything beyond that, Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus, *, bullseye, target, grey, gray, black, red, circle, Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a light beam on the same enemy, dealing damage, The beams from this item deal damage equal to 400% of your tear damage (4x damage multiplier for the beams only), The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance, Item Pool: Item Room, Greed Mode Item Room, Angel Room, A familiar host that sits on Isaac's head and has a 20% chance to block enemy shots, When a shot is blocked, Host Hat will fire 3 bullets back at the enemy, Causes you to become immune to explosions, but doesn't protect against stomps or shockwaves, Causes your shops to instantly restock their items when you buy them, New items generated by Restock are from the shop item pool, The cost increases exponentially every time you purchase an item. item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight. Attributes REPENTANCE - Dead Sea Scrolls now displays the name of the given effect, and can no longer give Kamikaze. Literature. When an enemy takes damage from an enemy projectile, it will attempt to target the enemy that fired it, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Judas, Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room, Zodiac will give you a random zodiac item effect that changes after every floor, Possible item effects include: Taurus, Aries, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, Gemini or Pisces, UNLOCK: Unlock this item by beating Greed Mode with The Lost, Tears now have a random chance to apply a poison effect, dealing damage equal to your tears each tick, for 2 ticks, Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick), Enemies that were poisoned by contact damage have a 20% chance to drop a black sin heart when killed. Can be used with Placebo to generate infinite batteries, Amnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). Strokes can cause sudden difficulty seeing, speaking, or walking. This familiar moves and shoots through the same inputs as Isaac, effectively acting as a second source of tears. The damage bonus is unaffected by both positive and negative damage multipliers. A dead sea in a dead land, grey and old. pink, red, eye, glow moms contacts mom contact, Upon use, this item causes Isaac to fart and poison any enemies in close proximity, The Bean deals 5 damage, then poisons enemies for 6 total ticks of damage, The poison deals your current tear damage per tick, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, team bean, #teambean, brown, kidney, An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals, UNLOCK: Unlock this item by beating Satan with Maggy, * angel room pool, god room pool, angel room item, baby, wings, A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range, UNLOCK: Unlock this item by beating the Dark Room with Azazel, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, black, grey, Monsters Curse of the Lost), Black Candle removes the teleportation effect of Cursed Eye, +15% chance of a devil or angel room opening after the boss fight, UNLOCK: Unlock this item by donating 150 pennies to the Shop, * curse room pool, shop room pool, shop item pool, grey, gray, Gives Isaac high damage tears with a short range, Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does, Tear damage starts at triple (300%) and decreases over range to eventually be 0%, * item room, treasure room, item room pool, red, bloody, eyeball, If the total sum of all your health is at one heart after taking damage, the necronomicon effect will activate, dealing 40 damage to the entire room, REPENTANCE - Missing Page 2 now doubles all black heart and Necronomicon damage (to 80 instead of the usual 40), Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper, A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it, If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Characters Taking it will cause Mom's Shadow to spawn and chase you. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! character damage multipliers), This item can only reduce your heart containers and will not increase them if you change back into a character with more health. Bosses Increases the maximum heart limit to 18. Isaac. purple, pink, circle, guppys collar, All of Isaac's tears now have a shield, allowing them to block an enemy projectile, If a tear blocks something, both Isaac's and the enemies tears are destroyed, * secret room pool, item room, treasure room, item room pool, white, lump, oval, When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room. 4 Item Pool: Item Room, Demon Beggar, Lust Miniboss, * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool, red, Item Pool: Item Room, Boss Room, Demon Beggar, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, green, Has a chance to drop from the Gluttony miniboss fight, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull, Can drop from an exploding slot machine while playing it, * slot machine, arcade machine, money, bill, cash, green, * boss rush pool, boss rush room, item room, treasure room, item room pool, grey, gray, x10, UNLOCK: Unlock this item by beating Mom's Heart 3 times, * secret room pool, the lost item pool, brown, noose, hang, Shows most icons on the map (Shops, Item Rooms, Boss Rooms etc. Poops spawned by Tainted ??? Seeds This is shown by the Azazel skin spreading on Isaac's face, After 4 rooms, Isaac's face will flash red. Using this card will also open a pathway of red rooms back to the regular floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Jacob, "May the darkness swallow all around you", When used, grants +1.5 Damage Up, turns your hearts to Bone hearts and the Spirit of the Night effect (Spectral tears and the ability to fly) for the current floor, Also gives the Curse of Darkness effect that can't be removed for the current floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lazarus, Creates a trapdoor to a guaranteed crawl space, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eden, When used, this copies the effect of the card, pill, rune, soul stone or active item you used most recently, UNLOCK: Unlock this card by defeating Mega Satan as Tainted Eden, Turns all pedestal items in the current room into rotating items, which cycle between the old item and a random new item every second, This allows you to effectively reroll items like with The D6, but choose the old item as well if you want, Tainted Isaac has this effect passively for all items, If you use more than one in the same room, each pedestal item will cycle through +1 random item, Items are chosen from the item pool related to the current item, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Isaac, When used, all enemies in the current room drop half a red heart that will disappear after 2 seconds if not picked up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Magdalene, When used, this Soul Stone creates Red rooms for every possible exit in the current room, Red outlines of doors appear where this Soul Stone will create exits for, See the Red Key item description for more information about these Red rooms behave, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Cain, Activates the Dark Arts item effect, which turns Isaac into a ghost for a few seconds. Pickups Based on the Steam Workshop mod created by Eufuu, UNLOCK: Unlock this trinket by having a lot of blue flies at once, While held this trinket gives your familiars homing shots, Added as part of the Afterbirth+ Booster Pack #5. The term "brimstone" (burn stone) comes from the King James Bible's mention of burning sulfur. UNLOCK: Unlock this item by defeating The Beast as ??? Tears have a 50% chance to be Blood Clot tears. These damage increases do not stack with each other. Smaller enemies spawn 2-3 tears, and bosses spawn a maximum of 16, Tears from this effect maintain tear modifiers and status effects that Isaac currently has, Isaac doesn't take damage from the tears created by this item, Every time you take damage, a tiny Isaac familiar will spawn, which follows you and shoots tears at nearby enemies that deal 1.3 Damage, The mini-Isaacs stay with you between floors, but can die if they take too much damage, Maximum number of mini-Isaacs is 16 at one time, Mini-Isaac's keep some of the abilities and appearance that Isaac has - e.g. However if you take damage a second time you die like the Lost does, Same effect as touching a white fire, but only lasts one room, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lost, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lilith, Spawns up to 25 random coins on the floor, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Keeper, Locusts are variants of blue flies, except they have special effects based on the color, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Apollyon, Gives you The Forgotten as a temporary familiar, with 2 Bone hearts and his bone weapon. The poison deals your tear damage per tick, for 2 ticks, Has no effect on Lilith, as she cannot fire tears, While firing tears constantly for 7.5 seconds, you spawn a poop cloud, which deals periodic damage to any enemies which come near it, The cloud deals damage equal to your base tear damage per tick, roughly 5 times per second, Clouds last 15 seconds before disappearing, The cloud can be pushed slightly by firing tears at it, Upon taking damage, Isaac starts to bleed, leaving a trail of blood and spraying blood tears everywhere which deal damage to nearby enemies, While bleeding, Isaac takes damage every 30 seconds, The blood sprays in the direction you are current firing, or just randomly near Isaac if not shooting your tears, The blood spray scales with your current tear damage and any future damage increases, This effect lasts until you pick up a red heart, Upon taking damage, this item gives a 25% chance to drop a full red heart, REPENTANCE - This entire item has been reworked, Enemy bullets have a 25% chance to be deflected back at the enemy, which will hurt them and apply the concussive status effect, causing it to be stunned for a few seconds, Every 20th tear fired will also fire a golden coin tear at the same time. Generally every interaction and synergy that applies to Chemical Peel also applies to Blood Clot. The laser hits up to 13 times if an enemy stays inside it for the duration, Has a chance to drop from the Envy and Super Envy miniboss fights, Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss, * item room, treasure room, item room pool, red, lips, white, eyes, UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss, *, black, white, face, eyes, mouth, golden chest pool, +10% chance of a devil/angel room opening while held, A second Pentagram will give an extra +5% chance, Counts as 1 of 3 evil items needed towards the Leviathan transformation, Item Pool: Boss Room, Curse Room, Devil Room, Demon Beggar, Crane Game, * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item, All floors guaranteed to have an Arcade except the Chest & Dark Room floors, Judas - Gives a passive Book of Belial item similar to Book of Virtues. at base damage of 3.5, that's 45 damage), Self-inflicted damage such as Blood Donation machines don't trigger this effect, Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide), Item Pool: Item Room, Greed Mode Item Room, Bomb Beggar. The laser deals damage equal to Isaac's damage and deals damage each tick. Your doctor will likely perform a physical examination, and you may undergo a venous . Based on the Steam Workshop mod (originally called Lightshot) created by Wyvern and TRPG, Pressing the CTRL key (R2 on PS4, RT on XB1, ZR on Switch) allows you to switch active items, Some items that give temporary effects like The Nail might deactivate if switched to the other slot, Added as part of the Afterbirth+ Booster Pack #4, UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2) in one run, Grants you a shield when entering the Boss Room, which prevents damage from 1 hit, then disappears. 3 or more keys = 100% chance. in The Chest floor as The Forgotten, Item Pool: Item Room, Greed Mode item Room, When picked up, this item replaces all of your red heart containers with 6 Bone Hearts, Every time you lose a bone heart, lots of bones fire in all directions damaging any enemies hit and you gain a permanent +0.5 Tears Up, For the Lost and Keeper characters, this item simply gives a permanent Tears Up, UNLOCK: Unlock this item by defeating The Lamb in the Dark Room floor as The Forgotten, Obtained by beating the Basement 1 boss within 1 minute, then bombing the large shadow that appears in the middle of the starting room, While held, Mom's Foot will stomp on you from above twice every few seconds, and she will continue to stomp for as long as you hold this item, Using the Broken Shovel will stop Mom stomping you for the rest of the current room (or current wave if you're in the boss rush or challenge room), Beating the Boss Rush while holding this item will drop the second half of the Broken Shovel, which combine to create Mom's Shovel, which is used to unlock The Forgotten character, Dropping the Broken Shovel will cause it to disappear if you leave the room, NOTE: This item will not drop unless you have beaten The Lamb at least once, Added as part of the Afterbirth+ Booster Pack #5 and used in the quest to unlock The Forgotten character, Drops after beating the Boss Rush while holding the other half of the Broken Shovel (see previous item for more details), Combines with the first Broken Shovel piece to create Mom's Shovel (see next item for more details), When used, spawns a trapdoor that leads to the next floor, Unlocks The Forgotten character when used on a mound of dirt that appears in a room in The Dark Room floor, Obtained by combining the two Broken Shovel pieces. 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